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Application of hydroxyapatite granules in posterolateral intertransverse lumbar spinal fusion

Buyong, Zunariah and Zakaria@Mohamad, Zamzuri and Khalid, Kamarul Ariffin and Zulkifly, Ahmad Hafiz and Abdel Wahab, Emad Mohamad Nafie and Ab Rahman, Jamalludin and Abdul Rashid, Mohd Amran (2012) Application of hydroxyapatite granules in posterolateral intertransverse lumbar spinal fusion. In: International Conference on Nanotechnology, ICONT 2012, 30 May – 01 June 2012, MS garden Hotel, Kuantan, Pahang. (Unpublished)

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Abstract

In many clinical disciplines used of bone graft is unavoidable such as to replace bone loss due to trauma, to fill in bone defect after tumour excision, for reconstructive surgery or spinal fusion. Calcium phosphate based hydroxyapatite is widely used bone graft substitute due to its similarity with the mineral components of bone matrix. This study was conducted to evaluate bone formation effect of this biomaterial in posterolateral intertransverse lumbar fusion, a novel site for its application. Twelve adult New Zealand white rabbits underwent bilateral intertransverse lumbar spinal fusion at L5-L6 vertebrae. One site of the animals was implanted with hydroxyapatite granules (HA group) while the contralateral sides received autograft and served as the control (AUTO group). Bone formation was assessed at 6 and 16 weeks by undecalcified histology and scanning electron microscopy. New bone was formed on the surface of hydroxyapatite granules and continually formed even at 16 weeks. Close contact between new bone and hydroxyapatite granules was demonstrated by scanning electron microscopy.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 11275/5178
Uncontrolled Keywords: hydroxyapatite, granules, posterolateral, intertransverse, lumbar, spinal, fusion
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Kulliyyah of Medicine > Department of Radiology
Depositing User: DR ZUNARIAH BUYONG
Date Deposited: 23 Jan 2019 16:45
Last Modified: 23 Jan 2019 16:45
URI: http://irep.iium.edu.my/id/eprint/11275

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