Haydar Ali Tajuddin, Amalina and Sukor, Norlela and Azizan, Elena Aisha and Kamaruddin, Nor Azmi and Omar, Ahmad Marzuki and Tan, Geok Chin and Mustangin, Muaatamarulain and Mohamed Mukari, Shahizon Azura and Alias, Azmi and Abd Latif, Kartikasalwah and Tay, Poh Sen and Kasim, Fauziah and Wan Ismail, Wan Ruza Iswati (2024) Tamoxifen and residual tumor volume in postoperative nonfunctioning pituitary neuroendocrine tumors: a pilot study. Journal of the Japan Endocrine Society, 100 (1). p. 312. ISSN 0029-0661 E-ISSN 2186-506X
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Abstract
Selective anti-estrogen receptor modulators (SERMs) have been shown to reduce the size of pituitary tumors. However, their clinical effect on nonfunctioning pituitary neuroendocrine tumors (NF-PitNET) in humans has not yet been established. We conducted a randomized controlled trial of tamoxifen versus conservative treatment in postoperative patients with residual tumors positive for estrogen receptor immunostaining to investigate the potential clinical impact on tumor volume. In this pilot study of 16 NF-PitNET patients, eight patients were randomized to receive 20-40 mg of tamoxifen daily for six months, while the other eight patients were treated conservatively. Serial MRI scans of the pituitary gland were performed at the beginning and end of the six months. Tamoxifen led to a significant reduction (> 25%) in tumor volume in three patients, while the tumor stabilized in the remaining five patients (p=0.046). In the control group, significant tumor growth was observed in three patients, while no significant change in tumor volume was observed in the remaining five patients. In general, tamoxifen was well tolerated. This pilot study illustrates the potential role of tamoxifen in postoperative residual NF-PitNET. This response to tamoxifen therapy needs to be further investigated in a longer-term study with a larger number of patients.
| Item Type: | Article (Meeting Abstract) |
|---|---|
| Uncontrolled Keywords: | Nonfunctioning pituitary neuroendocrine tumors, SERM, tamoxifen, gonadotroph adenoma |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RC Internal medicine > RC48.8 Rare diseases R Medicine > RC Internal medicine > RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology R Medicine > RC Internal medicine > RC66 Clinical cases |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Internal Medicine |
| Depositing User: | Dr Amalina Haydar Ali Tajuddin |
| Date Deposited: | 20 Jun 2024 14:53 |
| Last Modified: | 20 Jun 2024 17:31 |
| URI: | http://irep.iium.edu.my/id/eprint/112637 |
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