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Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan

Tee, H. P. and How, Soon Hin and Ab Rahman, Jamalludin and Mohamad Nor, Fariz Safhan and M., Mohd Sapian and Kuan, Yeh Chunn and S., Sapari (2009) Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan. Medical Journal of Malaysia, 64 (4). pp. 263-267. ISSN 0300-5283

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Abstract

A retrospective study was conducted to investigate 183 serologically-confirmed cases of dengue fever (DF) admitted from October 2004 to March 2005 in a large hospital in Pahang. Clinical and laboratory features, progress and outcome of these patients were analysed in order to identify risk factors associated with development of dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Individually, we found that older patients, secondary dengue infection, high baseline haematocrit levels, low platelet levels and prolonged activated partial thromboplastin time (APTT) ratio were significant associations with bleeding tendencies. Of these risk factors, haematocrit and APTT ratio were two independent significant risk factors on multivariate analysis. Older patients with primary infection and younger patients with secondary infection had significant bleeding tendencies. We also verified the validity of the haematocrit levels suggested as cut-off levels for plasma leakage for the Malaysian population by Malaysian Clinical Practice Guidelines for Dengue Infection in Adults (2003).

Item Type: Article (Journal)
Additional Information: 2987/1126
Uncontrolled Keywords: Dengue Haemorrhagic Fever, Dengue Shock Syndrome, Risk factors, Predictor, Haematocrit
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Community Health & Family Medicine
Depositing User: Dr Jamalludin Ab Rahman
Date Deposited: 21 Jul 2011 14:43
Last Modified: 10 Mar 2016 11:59
URI: http://irep.iium.edu.my/id/eprint/1126

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