Secondary metabolites from Aquilaria subintegra leaves and their radical scavenging activity

Ibrahim, Mastura and Syed Abdul Azziz, Saripah Salbiah and Wong, Chee Fah and Mohd Hassan, Norazian and Mhd Bakri, Yuhanis and M Abdel Aal, Abu-Baker (2024) Secondary metabolites from Aquilaria subintegra leaves and their radical scavenging activity. Malaysian Journal of Chemistry, 26 (2). pp. 27-32. ISSN 1511-2292 E-ISSN 2550-1658

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Abstract

The present study reports on the isolation, purification and antioxidant activity evaluation of the dichloromethane extract of Aquilaria subintegra Ding Hou leaves. Four compounds were successfully isolated and purified from the dichloromethane extract using column chromatography. Purification was monitored by thin layer chromatography, and four isolated compounds were identified by spectroscopic analyses such as NMR and mass spectrometry . These compounds were 5-hydroxy-7,4ʹ-dimethoxyflavone, luteolin-7,3ʹ,4ʹ-trimethyl ether, β- sitosterol and friedelin. Their antioxidant activity was determined using 2,2-diphenyl- 1-picrylhydrazyl (DPPH). All compounds exhibited weak antioxidant activity, with inhibition values of less than 30 % at the highest tested concentration (500 μg/mL). To the best of our knowledge, the current study is the first to report on the DPPH radical scavenging activity of isolated secondary metabolites from A. subintegra leaves.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Aquilaria subintegra, leaves; flavonoids; steroid; terpene; antioxidant activity
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Norazian Mohd Hassan
Date Deposited:	24 Apr 2024 12:43
Last Modified:	02 May 2024 10:50
URI:	http://irep.iium.edu.my/id/eprint/111884

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