Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger

Aminudin, Nurul Iman and Abdul Aziz, Ahmad Amzar and Zainal Abidin, Zaima Azira and Darnis, Deny Susanti and Bakhtiar, M. Taher (2024) Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger. Natural Product Research, 38 (9). pp. 1583-1590. ISSN 1478-6419 E-ISSN 1478-6427

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Abstract

Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a xanthorrhizol derivatives, namely (7R,10S)-10,11-dihydro-10,11-dihydroxyxanthorrhizol was produced in 60% yield from the biotransformation process utilizing A. niger. The structure of the compound was established by extensive spectroscopic methods and comparison with literature data. This biotransformation successfully afforded enantioselective dihydroxylation reaction via green chemistry route. This is the first report on both biotransformation of xanthorrhizol and utilization of A. niger as its biocatalyst.

Item Type:	Article (Journal)
Additional Information:	8125/111797
Uncontrolled Keywords:	Biotransformation, Aspergillus niger, enantioselective, dihydroxylation, green chemistry, xanthorrhizol
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Nurul Iman Aminudin
Date Deposited:	09 Apr 2024 09:03
Last Modified:	09 Apr 2024 09:03
URI:	http://irep.iium.edu.my/id/eprint/111797

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