GBA1 rs3115534 is associated with REM sleep behavior disorder in Parkinson’s disease in Nigerians

Ojo, Oluwadamilola Omolara and Bandres-Ciga, Sara and Makarious, Mary B. and Crea, Peter Wild and Hernandez, Dena G. and Houlden, Henry and Rizig, Mie and Singleton, Andrew B. and Noyce, Alastair J. and Nalls, Mike A. and Blauwendraat, Cornelis and Okubadejo, Njideka Ulunma and Mohamed, Wael Mohamed Yousef (2024) GBA1 rs3115534 is associated with REM sleep behavior disorder in Parkinson’s disease in Nigerians. Movements Disorders. pp. 1-6. ISSN 0885-3185 E-ISSN 1531-8257

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Abstract

Background:Rapid eye movement(REM) sleep behavior disorder (RBD) is an early fea-ture of Parkinson’s disease (PD) and dementia withLewy bodies (DLB). Damaging coding variants inGlucocerebrosidase (GBA1) are a genetic risk factorfor RBD. Recently, a population-specific non-codingrisk variant (rs3115534) was found to be associatedwith PD risk and earlier onset in individuals of Africanancestry.Objectives:We aimed to investigate whether theGBA1rs3115534 PD risk variant is associated withRBD in persons with PD.Methods:We studied 709 persons with PD and776 neurologically healthy controls from Nigeria. AllDNA samples were genotyped and imputed, and theGBA1rs3115534 risk variant was extracted. The RBDscreening questionnaire (RBDSQ) was used to assesssymptoms of possible RBD.Results:RBD was present in 200 PD (28.2%) and51 (6.6%) controls. We identified that the non-codingGBA1rs3115534 risk variant is associated with possi-ble RBD in individuals of Nigerian origin (β, 0.3640;standard error [SE], 0.103,P=4.093e�04), as well asin all samples after adjusting for PD status (β, 0.2542;SE, 0.108;P=0.019) suggesting that although non-coding, this variant may have the same downstreamconsequences asGBA1coding variants.Conclusions:Our results indicate that the non-codingGBA1rs3115534 risk variant is associated with anincreasing number of RBD symptoms in persons withPD of Nigerian origin. Further research is needed toassess if this variant is also associated withpolysomnography-defined RBD and with RBD symp-toms in DLB. © 2024 The Authors.Movement Disor-derspublished by Wiley Periodicals LLC on behalf ofInternational Parkinson and Movement DisorderSociety

Item Type:	Article (Journal)
Uncontrolled Keywords:	genetics; GBA1; rs3115534; Parkinson’s disease; REM sleep behavior disorder; Nigerians
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	18 Mar 2024 09:46
Last Modified:	21 Mar 2024 15:59
URI:	http://irep.iium.edu.my/id/eprint/111342

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