Biotransformation of curcumin by Streptomyces sp. K1-18 isolated from mangrove soil

Aminudin, Nurul Iman and Wan Jaafar, Wan Muhammad Shafiq and Mohd Amin, Nurul Mehiran Shafikah and Kamarul Baharin, Raudah and Zainal Abidin, Zaima Azira (2024) Biotransformation of curcumin by Streptomyces sp. K1-18 isolated from mangrove soil. Natural Product Research. ISSN 1478-6419 E-ISSN 1478-6427 (In Press)

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Abstract

Biotransformation is recognised as a green chemistry tool to synthesise diverse natural product analogues for valorisation of their chemistry and bioactivities. It offers significant benefits compared to chemical synthesis, given its cost-effectiveness and greater selectivity. In this work, a curcumin analogue, namely gingerenone A, was yielded from the biotransformation process catalysed by Streptomyces sp. K1-18. The structure of the compound was established by using mass spectrometry/mass spectrometry chemical profiling assisted with in silico fragmentation by MetFrag tool. This biotransformation successfully afforded a reduction reaction on curcumin. This is the first report on utilisation of Streptomyces sp. K1-18 as a biocatalyst for biotransformation of curcumin.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Biotransformation; curcumin; Streptomyces sp; chemical profiling; MetFrag; green chemistry
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr Nurul Iman Aminudin
Date Deposited:	20 Feb 2024 16:24
Last Modified:	06 Mar 2024 14:16
URI:	http://irep.iium.edu.my/id/eprint/110948

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