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Antibacterial activity of leaves extracts of Trifolium alexandrinum Linn. against pathogenic bacteria causing tropical diseases

Khan, Abdul Viqar and Ahmed, Qamar Uddin and Shukla, Indu and Khan,, Athar Ali (2012) Antibacterial activity of leaves extracts of Trifolium alexandrinum Linn. against pathogenic bacteria causing tropical diseases. Asian Pacific Journal of Tropical Biomedicine, 2 (3). pp. 189-194. ISSN 2221 1691

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Objective: To investigate antibacterial potential of Trifolium alexandrinum Linn. (Fabaceae, Egyptian clover) against seven G+ve and eleven G– ve hospitals isolated human pathogenic bacterial strains responsible for many tropical diseases. Methods: Non-polar and polar extracts of the leaves of T. alexandrinum i.e., hexane, dichloromethane (DCM), ethyl acetate (EtOAc), methanol (MeOH) and aqueous (AQ) extracts at five different concentrations (1, 2, 5, 10 and 15 mg/ml) were prepared to evaluate their antibacterial value. NCCL standards were strictly followed to perform antimicrobial disc susceptibility test using disc diffusion method. Results: Polar extracts demonstrated significant antibacterial activity against tested pathogens. EtOAc and MeOH extracts showed maximum antibacterial activity with higher inhibition zone and were found effective against seventeen of the tested pathogens. While AQ plant extract inhibited the growth of sixteen of the test strains. EtOAc and MeOH plant extracts inhibited the growth of all seven G+ve and ten of the G-ve bacterial strains. Conclusion: Present study strongly confirms the effectiveness of crude leaves extracts against tested human pathogenic bacterial strains causing several tropical diseases. Since Egyptian clover is used as a fodder plant, it could be helpful in controlling various infectious diseases associated with cattle’s as well.

Item Type: Article (Journal)
Additional Information: 4921/11054
Uncontrolled Keywords: Trifolium alexandrinum L.,Fabaceae Antibacterial activity, Pathogenic bacteria,Gram-positive bacteria,Gram-negative bacteria, Tropical disease, Infectious disease
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr Qamar Uddin Ahmed
Date Deposited: 14 Feb 2012 08:08
Last Modified: 14 Feb 2012 08:08
URI: http://irep.iium.edu.my/id/eprint/11054

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