Hypoglycemic and hypolipidemic effects of Oligomeris linifolia in Alloxan-induced diabetic mice

Ashiq, Aisha and Jan, Saleem and Khan, Yar Muhammad and Ullah, Faizan and Balaraman, Ashok Kumar and Azad, Abul Kalam and Khan, Tanveer Ahmad and Helal Uddin, A.B.M. (2023) Hypoglycemic and hypolipidemic effects of Oligomeris linifolia in Alloxan-induced diabetic mice. Current Trends in Biotechnology and Pharmacy, 17 (2). pp. 901-906. ISSN 0973-8916 E-ISSN 2230-7303

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Abstract

The current study was focused to evaluate the hypoglycemic and hypolipidemic effect of methanolic extracts of Oligomeris linifolia in Alloxan-induced diabetic mice. Albino mice were orally treated for 15 days with methanolic extract of Oligomeris linifolia at dose of 200 mg/kg body-weight. The antidiabetic effect was analyzed by measuring blood glucose (BG) at 0, 3, 6, 9, 12, and 15 days. Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Serum Bilirubin (SBR), Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), Urea, Creatinine, and triglycerides (TG) levels at sacrifice (day 16) were measured. Glibenclamide (10 mg/kg) was used as standard. Alloxan-induced diabetic mice showed adequate to significant increase in the level of BG, TC, TG, LDL-C, SBR, ALT, ALP, Urea, Creatinine, while HDL-C and body-weight were decreased as compared to control group (non-diabetic mice). Administration of plant methanolic extract to Alloxan-induced dabetic mice at a dose of 200 mg/kg body-weight resulted in a notable decrease in BG, TC, TG, LDL-C, SBR, ALT, ALP, Urea and Creatinine whereas HDL-C level and body-weight were increased markedly after 15 days as compared to diabetic control group. The methanolic extract at the dose of 200 mg/kg, produced similar results compared to group treated with Glibenclamide.

Item Type:	Article (Journal)
Additional Information:	4478/110044
Uncontrolled Keywords:	Oligomeris linifolia, White Albino mice, Antidiabetic activity, Lipid profile
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. A. B. M. Helal Uddin
Date Deposited:	02 Jan 2024 12:10
Last Modified:	02 Jan 2024 12:10
URI:	http://irep.iium.edu.my/id/eprint/110044

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