The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review

Azalan, Maryam Syahidah and Abdul Ghani, Radiah and Wallace, Heather M. (2023) The roles of polyamines in Malaysian herbs as a chemoprevention strategy: a scoping review. Asia Pacific Journal of Molecular Biology and Biotechnology, 31 (4). pp. 82-95. ISSN 0128-7451 E-ISSN 2672-7277

	PDF - Published Version Restricted to Repository staff only Download (542kB) | Request a copy
Preview	PDF - Supplemental Material Download (90kB) | Preview

Abstract

Maintaining normal polyamine levels is crucial for the physiological cellular process and differentiation because an imbalance of polyamine concentration affects the occurrence of neoplastic activities in many types of cancer diseases. Malaysian herbs have been purported to have anticancer properties that influence the polyamine’s bioavailability, leading to cancer cell death. Presently, the roles of polyamines in Malaysian herbs as chemoprevention have yet to be documented. Thus, this review aims to determine which Malaysian herbs have chemoprevention properties affecting polyamines and appraise the relationship between polyamine levels and Malaysian herbs and their cytotoxicity on cancer cells. The search, employing keywords like “Malaysian herbs”, “polyamines”, and “anticancer” or “chemoprevention”, yielded 256 articles. The articles were screened for their eligibility, befitting the objectives mentioned. The PRISMA-ScR checklist was employed to report the published findings from the databases. Thirteen articles meeting inclusion criteria were selected, highlighting 13 Malaysian herbs influencing the intracellular polyamines pathway. All herbs showed a significant reduction in ornithine decarboxylase (ODC) expression. In addition, Alpinia galanga and Aloe barbadensis showed an increase in catabolic polyamines expression, spermidine/spermine-N-acetyl transferase (SSAT) and spermine oxidase (SMO), respectively, leading to growth arrest and induction of apoptosis in cancer cells. The in vitro and in vivo studies demonstrated these herbs’ anti-proliferative effects on diverse cancer types, involving polyamine level modulation, intracellular dynamics, and chemopreventive mechanisms through apoptosis and anti-inflammatory responses. The findings underscore the potential of Malaysian herbs in cancer prevention by modulating the polyamine pathway.

Item Type:	Article (Journal)
Additional Information:	Dr Radiah is the corresponding author for this article. Please do not forget MyRA points for this and other journals too. This journal is index in Scopus (Q4) and MyCite. There is a collaboration with International party from Univ of Aberdeen. This also partly written by postgraduate student, Sr Maryam who are also the GRA for this FRGS grant.
Uncontrolled Keywords:	anticancer, chemoprevention, Malaysian herbs, medicinal plants, polyamines
Subjects:	Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Dr. Radiah Abdul Ghani
Date Deposited:	11 Jan 2024 15:01
Last Modified:	20 May 2024 12:34
URI:	http://irep.iium.edu.my/id/eprint/109954

Actions (login required)

View Item