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Treatment of osteoarthritis using Synvisc in New Zealand white rabbit

Abdul Hamid, Zahana and Zulkifly, Ahmad Hafiz and Mohamad Amri, Nur Fathonah and Abd. Rahim, Nour El Huda and Hassan, Habibah and Ibrahim, Mohd Zulfadzli and Mohd Jan, Nurul Hafiza and Abu Hassan, Salmah Anim and Mohd Zohari, Sarah Haryati and Zainal Abdullah, Muhamad Ezham and Abdul Jalil, Rosnani and Che Seman, Che Nor Zarida (2023) Treatment of osteoarthritis using Synvisc in New Zealand white rabbit. Malaysian Orthopaedic Journal, 16 (Supplement A). ISSN 1985-2533 E-ISSN 2232-111X

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INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide. Synvisc® is wildly used as a treatment for OA. This study will investigate the histological changes of OA in rabbits treated with Synvisc®. MATERIALS & METHODS: Twelve NZWR underwent surgery to induce OA. The rabbits were injected with intraarticular Synvisc® after 3 weeks. It is then euthanized at 3, 6, 12 and 24 weeks according to its group. The knee joint samples were collected and underwent hard tissue processing. The specimens were stained with Masson-Goldner staining. RESULTS: No intraoperative complications were observed. The Synvisc®-treated OA knees at 6 weeks (Figure 1) and at 12 (Figure 2) exhibited no inflammation. Improvement of cartilage thickness was noted. The cartilage is thicker in 12 weeks group compared to 6 weeks group. DISCUSSION: Rabbits treated with Synvisc® had less cartilage degeneration. This cartilage improvement was observed at 6 and 12 weeks after treatment. Specifically, the rabbits treated with Synvisc® improved the cartilage thickness. CONCLUSION: Synvisc® treatment showed histological improvements of OA in rabbits.

Item Type: Article (other)
Additional Information: 7285/109582
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery
R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Kulliyyah of Science
Depositing User: Dr Nour El Huda Abd Rahim
Date Deposited: 04 Jan 2024 10:34
Last Modified: 08 Jan 2024 09:56
URI: http://irep.iium.edu.my/id/eprint/109582

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