Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies

Mohd Zaini, Nur Nabilah and Wan Salleh, Wan Mohd Nuzul Hakimi and Arzmi, Mohd Hafiz and Salihu, Abubakar Siddiq and Ab Ghani, Nurunajah (2023) Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies. Natural Product Research. ISSN 1478-6419 E-ISSN 1478-6427 (In Press)

	PDF (Article - In Press) - Published Version Restricted to Repository staff only Download (2MB) | Request a copy
Preview	PDF (Scopus - In Press) - Supplemental Material Download (149kB) | Preview

Abstract

The chemical composition, antifungal, antibiofilm, and molecular docking studies of the essential oil obtained from Lindera caesia were investigated. A total of thirty-nine components (96.7%) were identified using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major components included terpinen-4-ol (26.3%), neo-intermedeol (23.2%), eudesma-4,11-dien-3-one (10.4%), and o-cymene (5.3%). The antifungal activity was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. The essential oil exhibited activity against C. albicans (MIC 125 µg/mL) and S. mutans (MIC 250 µg/mL), and increased the biofilm of C. albicans by 31.25% when treated with 500 µg/mL. The molecular docking study shows neo-intermedeol, eudesma-4,11-dien-3-one, α-selinene, and β-selinene as the good candidate to target Erg11 with a binding energy of −7.3 kcal/mol. These findings demonstrated that the essential oil may have potential in dental application for caries prevention.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Lindera caesia; essential oil; terpinen-4-ol; neo-intermedeol; Candida albicans; Streptococcus mutans
Subjects:	Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	03 Jan 2024 14:32
Last Modified:	15 Jan 2024 08:45
URI:	http://irep.iium.edu.my/id/eprint/109536

Actions (login required)

View Item