Mohamad Roslan, Muhamad Aidilfitri and Omar, Mohd Norfikri and Mohd Sharif, Nur Azlina and Ahmad Raston, Nurul Hanun and Arzmi, Mohd Hafiz and Neoh, Hui-Min and Ramzi, Ahmad Bazli (2023) Recent advances in single-cell engineered live biotherapeutic products research for skin repair and disease treatment. npj Biofilms and Microbiomes, 9 (1). E-ISSN 2055-5008
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Abstract
The human microbiome has emerged as a key player in maintaining skin health, and dysbiosis has been linked to various skin disorders. Amidst growing concerns regarding the side effects of antibiotic treatments, the potential of live biotherapeutic products (LBPs) in restoring a healthy microbiome has garnered significant attention. This review aims to evaluate the current state of the art of the genetically or metabolically engineered LBPs, termed single-cell engineered LBPs (eLBPs), for skin repair and disease treatment. While some studies demonstrate promising outcomes, the translation of eLBPs into clinical applications remains a significant hurdle. Substantial concerns arise regarding the practical implementation and scalability of eLBPs, despite the evident potential they hold in targeting specific cells and delivering therapeutic agents. This review underscores the need for further research, robust clinical trials, and the exploration of current advances in eLBP-based bioengineered bacterial chassis and new outlooks to substantiate the viability and effectiveness of eLBPs as a transformative approach in skin repair and disease intervention.
| Item Type: | Article (Review) |
|---|---|
| Additional Information: | 7855/108917 |
| Uncontrolled Keywords: | skin repair, microbiome, biotherapeutic |
| Subjects: | Q Science > QR Microbiology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences |
| Depositing User: | AP Ts Dr Mohd Hafiz Arzmi |
| Date Deposited: | 19 Dec 2023 09:59 |
| Last Modified: | 10 Mar 2024 12:36 |
| URI: | http://irep.iium.edu.my/id/eprint/108917 |
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