The relationship of vitamin B6 (pyridoxin) and postpartum depression: a scoping review

Abdul Ghani, Radiah and Ahmad Yusof, Nuraqilah Humaira (2023) The relationship of vitamin B6 (pyridoxin) and postpartum depression: a scoping review. International Journal of Allied Health Sciences (IJAHS), 7 (5). pp. 475-483. E-ISSN 2600-8491

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Abstract

Introduction: Postpartum depression (PPD) is one of the mental disorders that has a negative impact on a mother’s feelings after birth and causes them to lose interest in living their daily lives, primarily due to the chemical imbalance in the brain. Vitamin B6, or known as pyridoxine, is believed to be one of the chemicals in the brain which is involved in emotional regulation. However, the mechanism of action is unknown. Thus, the aim of this study is to review the influence of vitamin B6 and its relationship with the onset of PPD. Methods: Keywords "vitamin B6" and "vitamin B" and "pyridoxine" and "nutrition" and "PPD" and “perinatal depression” were employed in PubMed, SpringerLink, BioMed Central Journal and ScienceDirect. The screened articles were chosen based on their suitability for the topic of interest and published in English between 2000 and2023. The articles were chosen in accordance with PRISMA, and their eligibility was determined using inclusion and exclusion criteria. Results: A total of 3404 articles had been obtained initially and the resulting five articles met the criteria. It was revealed that the relationship between deficiency of vitamin B6 and PPD is still ambiguous. Two articles suggested the intake of vitamin B6 to an adequate level can be helpful to reduce the risk of PPD. In contrast, there are three studies that proposed that low vitamin B6 levels are not associated with PPD, hence increasing its intake during this period is found to be irrelevant. Conclusion: In conclusion, this review indicates that further investigation is warranted to determine the exact effect of vitamin B6 and its mechanism of action in emotional regulation. It is hoped that this benefits the mothers in prevention and treatment of PPD, thus improving the quality of their life.

Item Type:	Article (Review)
Additional Information:	4458/108746
Uncontrolled Keywords:	postpartum depression, pyridoxin, vitamin B6
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM216 Diet Therapy. Clinical Nutrition
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Dr. Radiah Abdul Ghani
Date Deposited:	11 Dec 2023 15:00
Last Modified:	27 Feb 2024 10:20
URI:	http://irep.iium.edu.my/id/eprint/108746

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