The clinical implications of Porphyromonas gingivalis and its detection methods – a systematic review

Shalihin, Mohd Shaiful Ehsan and Suhaimi, Nur Aina Nabilah and Hamzah, Hairul Aini and Abidin, Sulhi and Aidid, Edre Mohammad and Musa, Ramli (2023) The clinical implications of Porphyromonas gingivalis and its detection methods – a systematic review. Medical Journal of Malaysia, 78 (6). pp. 830-844. ISSN 0300-5283

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Abstract

Introduction: Mounting evidence has shown the significant correlation between periodontitis and the development of other comorbidities, such as cardiovascular disease due to periodontopathogenic bacterial migration and colonisation. As the main etiologic agent of periodontitis, the role of Porphyromonas gingivalis (P. gingivalis) has been widely explored as the main culprit and its early detection is crucial to control the exacerbation of diseases. This review aims to identify and summarise all clinical diseases that potentially developed due to the presence of P. gingivalis and discover all its detection methods that have been developed. Materials and Methods: Full-text articles of case report, case control, cohort and cross-sectional studies that were published from 1st January 2012 until 30th June 2022, were searched using PubMed, CINAHL and Scopus. Periodontal related diseases were excluded in this review due to its well-known associated disease with P. gingivalis. A comparison studies of detection methods were also excluded in this review. Results: Out of 612 articles that were screened, only 106 met the eligibility criteria to be selected for further review. Risk of bias was performed using FEAT principles and reviewers’ discussion. A total of 21 final articles that were reviewed showed significant correlation with P. gingivalis and were classified into several clinical domains. Twelve out of 13 detection methods showed high sensitivity and specificity with short duration analysis. Conclusion: Due to asymptomatic periodontal disease and the high prevalence of P. gingivalis-associated clinical diseases, this review suggests the need for oral public health awareness and early screening for the bacterium detection especially among elderly groups to maintain their quality of life.

Item Type:	Article (Review)
Additional Information:	6934/108440
Uncontrolled Keywords:	Clinical implication, Porphyromonas gingivalis, diseases, periodontal disease, detection method, systemic impact
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Prosthodontics Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Psychiatry
Depositing User:	Dr Mohd Shaiful Ehsan Shalihin
Date Deposited:	30 Nov 2023 14:30
Last Modified:	29 Dec 2023 23:20
URI:	http://irep.iium.edu.my/id/eprint/108440

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