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Effects of diet and exercise in reversing Type 2 Diabetes Mellitus: a systematic review

Ashar, Nurul Nadiah and Soe, May Khin and E. Zainudin, Engku Nuraishah Huda and Afdzal Rasif, Muhammad Naif Hafizin and Nazri, Amirah Farhana (2023) Effects of diet and exercise in reversing Type 2 Diabetes Mellitus: a systematic review. Pharmaceutical Sciences, 3 (2). pp. 104-125. E-ISSN 2582-8371

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Introduction: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder due to the body's ineffectiveness in responding to insulin. The prevalence of T2DM in Malaysia is increasing from year to year. Besides, diabetes is one of the Non-Communicable Diseases (NCDs) which are the leading cause of premature death due to its complications in Malaysia. Although pharmacological and surgical interventions are available in controlling T2DM, lifestyle modification provides an alternative way to reverse T2DM as the development of diabetes mellitus is highly related to lifestyle. The modifiable risk factors that lead to the causation of diabetes include being overweight or obese, a sedentary lifestyle, and being physically inactive. Losing weight through exercise and diet control is effective in delaying the progression of T2DM. It also improves cardiometabolic disease progression as an increase in insulin sensitivity. Diet and exercise are lifestyle interventions that can reduce weight. Thus, this systematic review aims to study the effectiveness of diet and exercise in reversing T2DM. Methods & Results: According to PRISMA guidelines, PubMed, Scopus, and Cochrane Library Database were used in this study for searching the related studies. 12 studies that investigated the effectiveness of diet and exercise in reversing T2DM were obtained and reviewed. The main search keywords were linked using the Boolean operators "AND" and "OR. Risk-of-bias assessment was done using JBI critical appraisal tools. Most of the studies reported a significant decline in BMI, fasting plasma glucose, and HbA1c values of intervention groups. Some studies reported T2DM remission and medication reduction after the intervention. Conclusion: Diet and exercise effectively reverse T2DM as significant weight loss was achieved. However, the long-term effect should be further evaluated as reviewed studies were limited in duration.

Item Type: Article (Journal)
Additional Information: This research paper is the result of final year students' project. (2023)
Uncontrolled Keywords: Diet, Exercise, T2DM, Reverse & Remission
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA644.3 Chronic and Noninfectious Diseases and Public Health
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Kulliyyah of Pharmacy
Depositing User: Dr May Khin Soe
Date Deposited: 10 Nov 2023 08:57
Last Modified: 10 Nov 2023 08:57
URI: http://irep.iium.edu.my/id/eprint/108021

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