Obesity in female young adults is linked to reduced methylation of IL-6

Wan Omar, Wan Fatein Nabeila and Abdullah, Aszrin and A.Talib, Norlelawati (2023) Obesity in female young adults is linked to reduced methylation of IL-6. In: The 11th Seoul International Congress of Endocrinology and Metabolism in conjunction with the 42nd Annual Scientific Meeting of Korean Endocrine Society, 26-28 Oct 2023, Seoul, Republic of Korea. (Unpublished)

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Abstract

Objective: Obesity is a complex condition with multiple contributing factors and is an epidemic in all population including young adults. Epigenetic modifications including DNA methylation, and inflammation has been associated with the etiology of obesity. Interleukin-6 (IL-6) is a pro-inflammatory cytokine linked to obesity. However, the interrelation between IL- 6 methylation, inflammation and obesity requires further investigation. In this study, we would like to investigate the correlation between IL-6 methylation, inflammation and obesity in young adults in males and females Methods: We assessed DNA methylation level of IL-6 gene promoter in peripheral blood leukocytes using bisulphite conversion and MethyLight assay. Data normality was evaluated using histogram, skewness, and kurtosis. Bivariate correlation was assessed using Pearson and Spearman’s correlation where appropriate. Results: We found inverse correlation between IL-6 methylation and BMI in female young adults (p = 0.037, r = –0.230), but not in males (p = 0.744). Meanwhile, high sensitivity C- reactive protein (hsCRP) showed positive association with body mass index and waist circumference in both sexes, with stronger association seen in female. There was significant association between IL-6 methylation and hsCRP in female (p = 0.033, r = -0.236) but not in males (p = 0.889). Conclusion: Lower IL-6 methylation is associated with higher hsCRP and higher BMI in female young adults. This finding could help to understand the different etiology in young population and considering specific treatment modality in treating this population.

Item Type:	Proceeding Paper (Poster)
Additional Information:	7963/107847
Uncontrolled Keywords:	epigenetics, DNA methylation, inflammatory markers, non-communicable diseases.
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Medicine
Depositing User:	Dr Wan Fatein Nabeila Wan Omar
Date Deposited:	28 Dec 2023 14:42
Last Modified:	28 Dec 2023 14:42
URI:	http://irep.iium.edu.my/id/eprint/107847

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