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Review on bone tumour sterilization using pasteurization for autologous bone reconstruction

Nik Abdul Adel, Nik Alyani and Abdul Razak, Ardilla Hanim and Khalid, Kamarul Ariffin (2023) Review on bone tumour sterilization using pasteurization for autologous bone reconstruction. Asian Journal of Medicine and Biomedicine (AJMB), 7 (2). pp. 109-115. E-ISSN 2600-8173

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Primary bone malignancies have incidence of 0.2% among all malignant tumours and 15% in all primary tumours. The commonest primary bone malignancy is osteosarcoma which the frequency had increased by 0.3% yearly over the last decade. Improvement in treatment of bone sarcoma by multidisplinary protocols involving diagnostic imaging, chemotherapy and surgical technique has improved the survival rate from 20% to 80%, hence paradigm of treatment shifted from amputation to limb preserving surgery. Bone reconstruction techniques varies from prosthetic replacement, allograft and bone autograft method. Bone autograft method needed sterilizing technique to devitalised tumour cells and pasteurization is a good option in maintaining its biomorphogenic properties when heated to 60°C -70°C for 30-40 minutes. This article will be discussing on histopathology findings, biomechanical outcome and clinical outcome of bone reconstruction using pasteurized autograft bone method. The advantages of pasteurization include less risk of disease transmission, no risk of allogenic immunogenicity, readily available, simple, less expensive and satisfactory bone remodelling. However, in certain cases it also shows deteriorating outcome in long term follow up due to issues with graft fracture, infection and resorption

Item Type: Article (Journal)
Additional Information: 8342/107717
Subjects: R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User: Dr Nik Alyani Nik Abdul Adel
Date Deposited: 02 Nov 2023 08:56
Last Modified: 02 Nov 2023 09:33
URI: http://irep.iium.edu.my/id/eprint/107717

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