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Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl

Mat So'ad, Siti Zaiton and Harun, Aiza and Mohd Hassan, Norazian and Che Mohd Ramli, Neni Kartini (2011) Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl. In: International Conference on Natural Products ICNP 2011, 14-16 November 2011, Putrajaya, Malaysia.

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Bioassay-guided isolation of methanol extract revealed that medium polar fraction of the extract contained a few compounds that inhibited the growth of dermatophytes skin caused diseases. This confirmed the traditional usages of the stem barks of Entada spiralis by Malays in the old time, as a soap, shampoo and scrub during the treatment of skin problems. Minimum inhibitory concentration of the fraction gave a significant value for the effect on selected dermatophytes which are T. rubrum, T. mentagrophytes and M. gypseum. Out of the five bioactive compounds isolated we will discuss one(1)of the compound which is proposed as a novel compound. The structural elucidation of the compound were based on spectroscopic analysis by using 1H-NMR, 13CNMR, DEPT, HMBC and HMQC. The mass spectrum, FTIR and UV were also used to support our data. From the structural elucidation,the compound is suggested as a triterpenoidal saponin which has never been reported elsewhere.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 5652/10684
Uncontrolled Keywords: natural products, stem bark, Entada spiralis Ridl., skin disease
Subjects: Q Science > QD Chemistry
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: Dr. Norazian Mohd Hassan
Date Deposited: 23 Feb 2012 15:11
Last Modified: 23 Feb 2012 15:11
URI: http://irep.iium.edu.my/id/eprint/10684

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