The effectiveness and application of Urtica dioica (stinging nettle) for musculoskeletal disorders: a systematic review and meta-analysis

Ahmad Zawawi, Sahira Syamimi and Zamli, Zaitunnatakhin and Saad, Nurulwahida (2023) The effectiveness and application of Urtica dioica (stinging nettle) for musculoskeletal disorders: a systematic review and meta-analysis. International Journal of Allied Health Sciences (IJAHS), 7 (1). pp. 2863-2874. E-ISSN 2600-8491

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Abstract

Musculoskeletal disorders (MSDs) are injuries of muscles, bones, tendons, joints, and ligaments commonly treated with medications like non-steroidal anti-inflammatory drugs and analgesic. However, undesired adverse effects with prolonged use have been reported. Urtica dioica (stinging nettle) has become one of the popular alternatives for MSDs as evident from literatures. This systematic review and meta-analysis were conducted to review the stinging nettle’s effectiveness as well as formulations and methods of administration in the MSDs treatment. PubMed, Google Scholar, IIUM Online Library, CINAHL, and OVID were searched for studies from the earliest publication. Mean pain reduction scores included standard mean difference values as a principal outcome measure. The risk of bias and certainty of evidence were assessed based on the Cochrane Handbook Review and GRADEpro tool, respectively. Of seven studies included, the stinging nettle treatment was shown to effectively reduce the musculoskeletal pain with only minor adverse effects were reported (29%). Oral ingestion (57%) and polyherbal formulation (57%) were frequently used in stinging nettle applications. Probable synergistic effect from polyherbal formulation and no definitive effects determined from the single formulations. Hence, there is a need for carefully designed RCTs for stinging nettle preparations in the MSDs treatment to strengthen clinical relevance.

Item Type:	Article (Review)
Additional Information:	5401/106781
Uncontrolled Keywords:	musculoskeletal disorders (MSDs), musculoskeletal pain, effectiveness, safety, Urtica dioica, stinging nettle
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Zaitunnatakhin Zamli
Date Deposited:	18 Sep 2023 12:15
Last Modified:	29 Feb 2024 13:26
URI:	http://irep.iium.edu.my/id/eprint/106781

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