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New considerations in the design of clinical trials of acute kidney injury

Md Ralib, Azrina and Pickering, John W. and Nejat, Maryam and Endre, Zoltan H. (2011) New considerations in the design of clinical trials of acute kidney injury. Clinical Investigation, 1 (5). pp. 637-650. ISSN 2041-6792

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Abstract

Acute kidney injury is a common and frequently fatal disease without an effective early intervention. The translation of promising experimental treatments to effective clinical trials has been hampered by the lack of a means to detect acute kidney injury early. Novel biomarkers of kidney injury have made early intervention possible and the first early intervention trial has been run. Emerging issues are the timing of biomarker measurement, the relationship of biomarker concentration with baseline renal function, and determining a primary outcome that best reflects renal function. A new generation of early intervention trials with increased prospects of finding effective therapies are now possible utilizing currently available novel biomarkers. Proposed new outcome measures will decrease the likelihood of negative trials as a result of poor design.

Item Type: Article (Journal)
Additional Information: 3934/10620
Uncontrolled Keywords: acute kidney injury • cystatin C • EARLYARF trial • neutrophil gelatinase-associated lipocalin
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User: Dr Azrina Md Ralib
Date Deposited: 27 Jan 2012 16:00
Last Modified: 27 Jan 2012 16:00
URI: http://irep.iium.edu.my/id/eprint/10620

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