IIUM Repository

The impact of potentially inappropriate medications and polypharmacy on 3-month hospital readmission among older patients: a retrospective cohort study from Malaysia

Akkawi, Muhammad Eid and Abd Aziz, Hani Hazirah and Nahas, Abdul Rahman Fata (2023) The impact of potentially inappropriate medications and polypharmacy on 3-month hospital readmission among older patients: a retrospective cohort study from Malaysia. Geriatrics, 8 (3). pp. 1-10. E-ISSN 2308-3417

PDF (SCOPUS) - Supplemental Material
Download (183kB) | Preview
[img] PDF (Article) - Published Version
Restricted to Registered users only

Download (274kB) | Request a copy


Abstract: Introduction: Potentially inappropriate medications (PIMs) use and polypharmacy are two issues that are commonly encountered among older people. They are associated with several negative outcomes including adverse drug reactions and medication-related hospitalization. There are insufficient studies regarding the impact of both PIMs and polypharmacy on hospital readmission, especially in Malaysia. Aim: To investigate the possible association between polypharmacy and prescribing PIMs at discharge and 3-month hospital readmission among older patients. Materials and method: A retrospective cohort study involved 600 patients ≥60 years discharged from the general medical wards in a Malaysian teaching hospital. The patients were divided into two equal groups: patients with or without PIMs. The main outcome was any readmission during the 3-month followup. The discharged medications were assessed for polypharmacy ( ≥five medications) and PIMs (using 2019 Beers’ criteria). Chi-square test, Mann–Whitney test, and a multiple logistic regression were conducted to study the impact of PIMs/polypharmacy on 3-month hospital readmission. Results: The median number for discharge medications were six and five for PIMs and non-PIMs patients, respectively. The most frequently prescribed PIMs was aspirin as primary prevention of cardiovascular diseases (33.43%) followed by tramadol (13.25%). The number of medications at discharge and polypharmacy status were significantly associated with PIMs use. Overall, 152 (25.3%) patients were re-admitted. Polypharmacy and PIMs at discharge did not significantly impact the hospital readmission. After applying the logistic regression, only male gender was a predictor for 3-month hospital readmission (OR: 2.07, 95% CI: 1.022–4.225). Conclusion: About one-quarter of the patients were admitted again within three months of discharge. PIMs and polypharmacy were not significantly associated with 3-month hospital readmissions while male gender was found to be an independent risk factor for readmission.

Item Type: Article (Journal)
Uncontrolled Keywords: older patients; polypharmacy; potentially inappropriate medication; hospital readmission; Malaysia
Subjects: R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology (including Cancer) > RC952 Geriatrics
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM147 Administration of Drugs and Other Therapeutic Agents
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User: Dr. Muhammad Eid Akkawi
Date Deposited: 24 Jul 2023 14:38
Last Modified: 24 Jul 2023 14:50
URI: http://irep.iium.edu.my/id/eprint/105725

Actions (login required)

View Item View Item


Downloads per month over past year