The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats

Abdullah, Aszrin and Abdul Razak, Tariq and Mohd Noor, Noriah (2011) The effect of chronic 1,2,3,4-Tetrahydroisoquinolines administration in young spontaneously hypertensive rats. In: 5th Conference of Asian Association Of School Of Pharmacy, 16-19 June 2011, Bandung.

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Abstract

Adrenaline plays a role in the pathogenesis of essential hypertension through excessive stimulation of adrenomedullary hormonal system. Pharmacological inhibition of adrenomedullary hormonal system should result in chronic, sustained blood pressure(BP) reduction. We propose the use of 1,2,3,4-tetrahydroisoquinolines (THIQ) as a phenylethanolamine N-methyltransferase (PNMT) inhibitor in young spontaneously hypertensive rats will result in sustained BP reduction. 14 young male and female SHRs weighing between 160 and 270g were studied. Eight study rats administered with daily THIQ (Treated) and 6 age-matched controls (Control) were included. Indirect systolic blood pressure (SBP) was measured by tail cuff method prior to drug study (baseline), 2-hours post-administration on D1, D3 (subchronic), D7 and D14. The mean baseline SBP in Treated and Control SHRs were 163.15 + 16.26 vs 171.69 + 17.27 mmHg respectively (p=1.00). The mean SBP at D7 were 128.31 + 19.36 vs 173.06 + 19.62 mmHg respectively (p=0.035). The mean SBP at D14 were 129.00 + 13.34 vs 180.08 + 14.59 mmHg respectively (p=0.041). There was no significant difference in the mean weight and age of the two groups throughout the study duration. Chronic 1,2,3,4-tetrahydroisoquinolines administration is an effective inhibitor of phenylethanolamine N-methyl transferase, the enzyme that catalyzes the terminal step in the biosynthesis of adrenaline, thereby resulting in sustained BP reduction in young spontaneously hypertensive rats.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	3960/10564
Uncontrolled Keywords:	adrenaline, hypertension, adrenomedullary hormonal system
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Prof Noriah Mohd Noor
Date Deposited:	23 Feb 2012 11:28
Last Modified:	23 Feb 2012 11:28
URI:	http://irep.iium.edu.my/id/eprint/10564

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