Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis

Khaldun, Al-Azzam and Elbashir, Abdalla A. and Elbashir,, Mohammed A and Saad, Bahruddin and Abd Hamid, Shafida (2009) Simultaneous determination of atenolol and chlorthalidone in pharmaceutical preparations by capillary-zone electrophoresis. Analytical letters, 42 (10). pp. 1458-1470. ISSN 0003-2719

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Abstract

A capillary zone electrophoresis (CZE) method for the simultaneous determination of the β-blocker drugs atenolol and chlorthalidone in pharmaceutical formulations has been developed. The CZE separation was performed under the following conditions: capillary temperature, 25°C; applied voltage, 25 kV; 20 mM H3PO4–NaOH running buffer (pH 9.0); and detection wavelength, 198 nm. Phenobarbital was used as internal standard. The method was validated and showed not only good precision and accuracy but also good robustness. The method has been successfully applied to the simultaneous determination of both atenolol and chlorthalidone in pharmaceutical tablets.

Item Type:	Article (Journal)
Additional Information:	5980/10561
Uncontrolled Keywords:	atecapillary zone electrophores, chlorthalidon, pharmaceutical preparations
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	Ms Rosyidah Taju Rahim
Date Deposited:	08 Feb 2012 07:44
Last Modified:	08 Feb 2012 07:44
URI:	http://irep.iium.edu.my/id/eprint/10561

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