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A current review of local metronidazole antibiotics for the treatment of periodontal disease

Mohd Zavi, Nora Azirah and Mohamed Halim, Muhammad Lutfi and Mohamad, Mohd Yusof (2023) A current review of local metronidazole antibiotics for the treatment of periodontal disease. Revelation and Science, 13 (1). pp. 26-38. ISSN 2229-9645 E-ISSN 2229-9947

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Periodontal disease affects around 14.5% of the global adult population. It affects the tooth's supporting tissues, causing inflammation and tooth loss. Periodontitis treatment aims to prevent further disease progression by restoring the lost tissue and preventing bacterial infection. Nevertheless, periodontal breakdown may still occur post-treatment due to the periodontal pathogens. Antibiotics were utilized to control and prevent the infection. Local drug delivery system (LDD) is being developed to deliver the antibiotic due to its site-specific benefits. Metronidazole (MET) is widely used to treat periodontal nfection following treatments due to its efficacy against obligate anaerobes and broad-spectrum characteristics. Despite its advantages, MET is attributed to systemic side effects. Therefore, this article aimed to review in vitro, in vivo, and clinical studies on the current local application of MET to treat periodontal diseases. 13 relevant research articles were analysed and provide valuable insights into the local application of metronidazole for periodontal treatment.

Item Type: Article (Journal)
Uncontrolled Keywords: metronidazole; local drug delivery; periodontitis, antibiotic
Subjects: Q Science > QR Microbiology
R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences > Department of Physical Rehabilitation Sciences
Kulliyyah of Allied Health Sciences
Depositing User: Dr Mohd Yusof Mohamad
Date Deposited: 17 Jul 2023 09:17
Last Modified: 17 Jul 2023 09:19
URI: http://irep.iium.edu.my/id/eprint/105539

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