Wan Abdul Khodir, Wan Khartini and Ismail, Mohamad Wafiuddin and Abd Hamid, Shafida and Daik, Rusli and Darnis, Deny Susanti and Bakhtiar, M. Taher and Guarino, Vincenzo (2023) Synthesis and characterization of Ciprofloxacin loaded Star-Shaped Polycaprolactone–Polyethylene glycol hydrogels for oral delivery. Micromachines, 14 (7). pp. 1-16. E-ISSN 2072-666X
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Abstract
The administration of poorly water-soluble drugs represents a relevant problem due to the low body fluids transport efficiency through hydrophilic hydrogels. Star-shaped co-polymers, i.e., amphiphilic polymers such as those with a hydrophobic core and a hydrophilic outer shell, can be used to improve weak interactions with drugs, with relevant benefits in terms of administration and controlled delivery. In this work, two different co-polymers, four-arm star-shaped PCL–PEG and six-arm star-shaped PCL–PEG, were synthesized via ring-opening polymerization to be loaded with ciprofloxacin. 1H-NMR and FTIR analyses confirmed that PCL arms were successfully grafted to the mPEG backbone, while DSC analysis indicated similar crystallinity and melting point, ranging from 56 to 60 ◦C, independent of the different co-polymer architecture. Therefore, both star-shaped PCLPEGs were investigated as cargo device for ciprofloxacin. No significant differences were observed in terms of drug entrapment efficiency (>95%) and drug release, characterized by a pronounced burst followed by a slow sustained release, only slightly affected by the co-polymer architecture. This result was also confirmed with curve fitting via the Korsmeyer–Peppas model. Lastly, good antibacterial properties and biocompatibility exhibited in both star-shaped PCL–PEG co-polymers suggest a promising use for oral delivery applications.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | PCL arms; star co-polymers; hydrogels; ciprofloxacin; drug delivery |
| Subjects: | Q Science > QD Chemistry |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science > Department of Chemistry |
| Depositing User: | Dr Shafida Abd Hamid |
| Date Deposited: | 13 Jul 2023 10:36 |
| Last Modified: | 14 May 2024 12:14 |
| URI: | http://irep.iium.edu.my/id/eprint/105475 |
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