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High-mobility group box 1 (HMGB1) protein in Parkinson’s disease research: A 10-year bibliometric analysis

Razali, Khairiah and Mohamed, Wael Mohamed Yousef (2023) High-mobility group box 1 (HMGB1) protein in Parkinson’s disease research: A 10-year bibliometric analysis. Journal of Integrative Neuroscience, 22 (4). pp. 1-8. ISSN 0219-6352 E-ISSN 1757-448X

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Background: Parkinson’s disease (PD), the most prevalent motoric neurodegenerative disease, has been intensively studied to bettercomprehend its complicated pathogenesis. Chronic neuroinflammation is a major factor contributing to the development of PD. Re-portedly, high-mobility group box 1 (HMGB1) protein is capable of mediating neuroinflammatory response. In this regard, knowledgemapping of the research linking HMGB1 to PD is necessary.Objective: Herein, we perform a dynamic and longitudinal bibliomet-ric analysis to explore the hotspots and current trends of HMGB1-related PD publications during the past decade.Methods: All PDpublications focusing on HMGB1 protein were retrieved from the PubMed database using the search terms “Parkinson’s disease” and“hmgb1”. Using filters, only English articles published between 2011 and 2022 were selected. The Bibliometrix and Biblioshiny pack-ages from R software were used to conduct the bibliometric analysis.Results: The filtered search identified 47 articles (34 originalarticles and 13 review articles), published between 2011 and 2022. There was an increase trend in the number of articles published,with an annual growth rate of 19.35 percent. In terms of research and scientific collaboration in this field, the United States is in thelead, followed by China, Malaysia, and Australia. Compared to other countries, the United States and China had the highest level ofcollaboration in this research area. Neuroinflammation, microglia, and receptor for advanced glycation end-products (RAGE) representthe top three frontiers and hotspots for HMGB1-related PD research. According to the thematic evolution analysis, over the last decade,PD, HMGB1 and microglia were addressed individually, however, since 2017, these topics were frequently discussed within the samecluster: neuroinflammation. Furthermore, PD,HMGB1, andneuroinflammationdomainsco-occurredinmajorityoftheresearchdiscus-sion.Conclusions: The link between HMGB1 and PD was realized a decade ago and becomes increasingly important over time. Ourfindings can aid scholars in comprehending the global context of HMGB1/PD relationship and provide significant insights for future PDresearch

Item Type: Article (Journal)
Uncontrolled Keywords: Parkinson’s disease; high-mobility group box 1; bibliometric analysis; neuroinflammation; microglia
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine
Depositing User: Dr Wael Mohamed
Date Deposited: 11 Jul 2023 10:23
Last Modified: 11 Jul 2023 10:29
URI: http://irep.iium.edu.my/id/eprint/105430

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