A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

Ahda, Mustofa and Jaswir, Irwandi and Khatib, Alfi and Ahmed, Qamar Uddin and Mahfudh, Nurkhasanah and Ardini, Yunita Dewi (2023) A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study. International Journal of Food Properties, 26 (1). pp. 1414-1425. ISSN 1094-2912 E-ISSN 1532-2386

	PDF - Published Version Restricted to Registered users only Download (2MB) | Request a copy
Preview	PDF - Supplemental Material Download (193kB) | Preview

Abstract

Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for reducing glucose. The mechanisms of action of different herbal medicines used might be also different. The reduction of blood glucose levels by Aloe vera, Andrographis paniculata, and Trigonella foenum-graecum through mini-mum 3 mechanisms of action, such as increased GLP-1 secretion and inhib-ited amylase, glucosidase, and SGLT 2. While Andrographis paniculata has more than 4 mechanisms of action, such as increasing GLP secretion, activat-ing PPAR ɣ-receptor, and also inhibiting amylase, glucosidase, and SGLT 2 but it did not inhibit DPP 4 in diabetic patients.

Item Type:	Article (Review)
Uncontrolled Keywords:	Anti-diabetes; herbal medicines; mechanisms of action; clinical study
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM147 Administration of Drugs and Other Therapeutic Agents
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART) Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Paediatric Dentistry and Dental Public Health Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	27 Jun 2023 15:47
Last Modified:	06 Sep 2023 09:41
URI:	http://irep.iium.edu.my/id/eprint/105250

Actions (login required)

View Item