Nutrigenomics and trace elements: hopes and hypes for Parkinson’s Treatment

Soliman, Al-Hassan and Mohamed, Wael Mohamed Yousef (2023) Nutrigenomics and trace elements: hopes and hypes for Parkinson’s Treatment. In: Trace Elements in Brain Health and Disease. Nutritional Neurosciences, 1 . Springer Singapore, Singapore, pp. 47-69. ISBN 978-981-99-1512-5

PDF - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

The most common kind of neurological condition leading to mobility disability is Parkinson’s disease (PD). This illness is characterized by a wide variety of motor symptoms, such as tremors, rigidity, bradykinesia or akinesia, and postural instability. Nevertheless, motor and non-motor symptoms coexist in a person with PD. In many cases, a clinical diagnosis of PD may be more reliable. Nevertheless, a wide variety of other lab tests may help differentiate PD from other forms of parkinsonism. Treatments for PD include the use of levodopa. It is the gold standard treatment for motor symptoms associated with PD. Levodopa crosses the blood–brain barrier and is converted to dopamine in the substantia nigra’s dopamine-receiving neurons (SN). Antioxidants including melatonin, resveratrol, green tea, and lipoic acid have gained widespread attention as potential neuroprotective agents in recent years. As our understanding of nutrigenomics grows, we will be able to pinpoint the role that alterations in diet play in the breakdown of normally functioning systems and the development of pathological diseases. This information might be used to improve neuroprotective mechanisms by dietary changes and the introduction of novel, more beneficial natural compounds. Such mechanisms include increased expression of health-promoting genes and decreased expression of disease-promoting genes after brain damage or other pathologies. There are numerous potential neuroprotective techniques that might include this approach.

Item Type:	Book Chapter
Additional Information:	ISSN: 2730-6712, E-ISSN: 2730-6720
Uncontrolled Keywords:	Nutrigenomics · Parkinson’s disease · Brain health · Trace elements ·Nutrition
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	20 Jun 2023 12:31
Last Modified:	20 Jun 2023 12:33
URI:	http://irep.iium.edu.my/id/eprint/105181

Actions (login required)

View Item