Streptococcus gallolyticus infection: A neglected marker for colorectal cancer?

Ismail, Che Muhammad Khairul Hisyam and Mohammad Aidid, Edre and Hamzah, Hairul Aini and Shalihin, Mohd Shaiful Ehsan and Md Nor, Azmi (2023) Streptococcus gallolyticus infection: A neglected marker for colorectal cancer? Arab Journal of Gastroenterology, 24 (3). pp. 163-167. ISSN 1687-1979 E-ISSN 2090-2387

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Abstract

Background and study aims Colorectal cancer (CRC) is the second most common cancer in Malaysia and mostly detected at advanced stages due to lack of awareness of CRC symptoms and signs. CRC pathogenesis is multifactorial, and there is ambiguous evidence on association of Streptococcus gallolyticus infection with CRC that needs further attention. Thus, a case–control study was conducted to determine whether S. gallolyticus infection is a predictor for CRC occurrence among patients attending Sultan Ahmad Shah Medical Centre@IIUM (SASMEC@IIUM). Patients and methods A total of 33 stool samples from patients diagnosed with CRC and 80 from patients without CRC attending surgical clinic of SASMEC@IIUM were collected and analyzed with iFOBT test and PCR assay to detect S. gallolyticus. Results In this study, the proportion of S. gallolyticus infection was higher among patients with CRC (48.5%) compared with the control group (20%). Univariate analysis shows that occult blood in stool, S. gallolyticus infection and family history were significantly associated with the development of CRC (P < 0.05). Using the multivariate logistic regression model, positive stool PCR for S. gallolyticus had the lowest relative standard error and almost five times the odds of developing CRC after adjusting other factors (adjusted odds ratio = 4.7, 95% confidence interval = 1.7–12.6, relative standard error = 59.6%). Conclusion This finding suggests that S. gallolyticus infection was the strongest predictor of CRC’s development in our study and potentially serves as a predictive marker for early detection of disease progression.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Case-control study; Colorectal cancer; Multivariate logistic regression; Predictors; Stool PCR; Streptococcus gallolyticus
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Surgery
Depositing User:	Dr Hairul Aini Hamzah
Date Deposited:	10 Oct 2023 15:18
Last Modified:	05 Feb 2024 09:55
URI:	http://irep.iium.edu.my/id/eprint/105136

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