Salivary IgA as a potential biomarker for early childhood caries detection

Mustafa Al-Ahmad, Basma Ezzat (2023) Salivary IgA as a potential biomarker for early childhood caries detection. In: 7th International Conference on Dentistry, 26th May 2023, Virtual Conference. (Unpublished)

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Abstract

Early Childhood Caries (ECC) prevalence was reported quite high in many countries including Malaysia. Dental caries is a predominant oral disease that results from chronic exposure to the disparity of numerous factors. Saliva is the most significant essential factor of dental caries, which provides physical and biological defensive mechanisms. The humoral immunologic response can regulate caries, especially salivary secretory immunoglobulin A (s-IgA) which has immunological control over dental caries and presumably prevents the adherence of cariogenic microorganisms to the hard surfaces in addition to the inhibition of the activity of glucosyl transferases. There is an association between caries and increased levels of sIgA, which may be due to many reasons like the response to the mild exposition of dental caries as a form of a protective mechanism of the body against caries attack, which will stimulate the production of sIgA that plays a role in oral homeostasis. Still, the relationship between sIgA and dental caries is controversial and needs further investigation.

Item Type:	Conference or Workshop Item (Slide Presentation)
Uncontrolled Keywords:	Salivary IgA, Biomarker, Early Childhood Caries
Subjects:	R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry
Depositing User:	Dr Basma Al-Ahmad
Date Deposited:	13 Jun 2023 10:22
Last Modified:	13 Jun 2023 10:22
URI:	http://irep.iium.edu.my/id/eprint/105056

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