Patient characteristics and risk factors contributing to disease progression among hospitalised patients with Covid-19: lesson from Malaysia

Othman, Nurul Syafiqah and Mohd. Zin, Che Suraya and Mohd Taufek, Nor Hidayah (2023) Patient characteristics and risk factors contributing to disease progression among hospitalised patients with Covid-19: lesson from Malaysia. International Journal on Integration of Knowledge, 1 (1). pp. 27-39. E-ISSN 2990-9392

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Abstract

Background: Patients who were hospitalised with severe COVID-19 infection could progress to severe conditions due to various factors, whereas some patients may recover to mild conditions quickly. There was limited information regarding characteristics and factors affecting disease progression in this population in Malaysia. This study aimed to investigate patient characteristics and risk factors contributing to disease progression among COVID-19 patients during hospitalisation. Methods: A retrospective cross-sectional study using electronic medical record data from COVID-19 patients admitted to two public hospitals in East Coast Malaysia from February 2020 to August 2021 was conducted. This study included patients with asymptomatic or mild condition (stage 1 – stage 3) upon hospital admission and progressed to severe condition (stage 4 – stage 5) during hospitalisation. Results: A total of 163 patients were included (57% male) with the age of (mean±SD, 62.3 ±14.0 years). Multivariable logistic regression associated with COVID-19 disease progression included elderly (OR, 1.06; 95% CI, 1.04, 1.08; p = ≤0.05), diabetes mellitus (OR, 2.27; 95% CI, 1.27, 4.06; p = 0.006), chronic kidney disease (OR, 4.87; 95% CI, 1.92, 12.38; p=0.001), and presented with more than three COVID-19 symptoms (OR, 9.80; 95% CI, 6.08-15.81, p = ≤0.05). Conclusion: Risk factors for COVID-19 disease progression included elderly patients, comorbidities of diabetes mellitus, chronic kidney disease or more than three COVID-19 symptoms. Close monitoring and early intervention should be implemented for these patients to prevent the disease progression and poor prognosis.

Item Type:	Article (Journal)
Uncontrolled Keywords:	COVID-19, disease progression, risk factors, patient characteristics, Malaysia
Subjects:	R Medicine > RA Public aspects of medicine > RA643 Communicable Diseases and Public Health
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Nor Hidayah Mohd Taufek
Date Deposited:	19 May 2023 09:00
Last Modified:	19 May 2023 09:03
URI:	http://irep.iium.edu.my/id/eprint/104645

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