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Nexus between periodontal disease and chronic kidney disease: a narrative review

Abdul Rahman, Nurul Aliya and Hanafi, Muhammad Hafiz and Ibrahim, Hanim Afzan and Omar, Julia and Chaudhry, Ahmed and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Kassim, Nur Karyatee (2023) Nexus between periodontal disease and chronic kidney disease: a narrative review. Bangladesh Journal of Medical Science, 22 (2). pp. 260-271. ISSN 2223-4721 E-ISSN 2076-0299

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Background: Several decades of research have established the relationships between systemic diseases and periodontal diseases. Chronic kidney disease (CKD) is a chronic medical condition in which the homeostatic and emunctory activity of the kidneys is progressively declines. Periodontitis is a complex, polymicrobial disease that involves both the host and the environment. Tissue destruction is primarily associated with the host’s hyperresponsiveness, resulting in the release of inflammatory markers. Aim: This paper reviewed the evidence linking CKD, inflammatory markers, and periodontal disease and the effect of periodontal therapy on inflammatory markers and kidney function as well as dental parameters. Setting and Design: The sources of data were compiled and reviewed from MEDLINE, SCOPUS and Web of Sciences from 2010 to 2021. Result and Discussion: This review identifies biologically plausible bidirectional nexus between periodontitis and CKD. Periodontitis has emerged as non-traditional risk factor of CKD and vice versa. In addition, inflammatory markers are considered to play a role in the linkages between periodontitis and CKD. Recent study, has linked an increase in the production of inflammatory markers to a poorer renal outcome in patients with CKD. Periodontal therapy is effective in lowering the inflammatory markers levels and periodontal parameters as well as halting the progression of CKD. Conclusion: Understanding these links may help in identifying high-risk individuals and providing essential care at an early stage.

Item Type: Article (Review)
Uncontrolled Keywords: chronic kidney disease; periodontitis; systemic inflammation; non-surgical periodontal therapy; risk factor; inflammatory markers
Subjects: R Medicine > R Medicine (General)
R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine
Depositing User: Mrs Norsyafini Ahmad Marzuki
Date Deposited: 05 May 2023 10:26
Last Modified: 05 May 2023 10:26
URI: http://irep.iium.edu.my/id/eprint/104544

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