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Tualang honey-mediated silver nanoparticles attenuate hippocampal oxidative stress in kainic acid-induced male rats

Hasim, Hidani and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Rao, Pasupuleti Visweswara and Muthuraju, Sangu and Asari, Mohd Asnizam (2022) Tualang honey-mediated silver nanoparticles attenuate hippocampal oxidative stress in kainic acid-induced male rats. Biomedical Research and Therapy, 9 (12). pp. 5465-5475. E-ISSN 2198-4093

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Introduction: Kainic acid (KA) has been widely used to study the mechanism of excitotoxicity-induced neurodegeneration and to investigate neurodegenerative therapeutic intervention. The present study aimed to investigate the protective effects of Tualang honey-mediated silver nanoparticles (THSN) against oxidative stress in the hippocampus of KA-induced rats. Methods: Male Sprague Dawley rats (n = 72) were randomized into six groups: i) control, ii) THSN 10 mg, iii) THSN 50 mg, iv) KA only, v) THSN 10 mg + KA, and vi) THSN 50 mg + KA. The animals were administered distilled water or THSN (10 or 50 mg/kg), according to their respective groups, five times at 12 h intervals before being injected subcutaneously with saline or KA (15 mg/kg). Animals were sacrificed after 24 h and 5 days of KA induction. Malondialdehyde (MDA), total nitrate/nitrite (NOx), protein carbonyl (PCO), glutathione (GSH), total antioxidant status (TAS), and catalase (CAT) activity in the hippocampal tissue were measured using commercially available ELISA kits. Results: THSN pre-treatments significantly improved oxidative status in the hippocampus by decreasing the MDA, NOx, and PCO levels while increasing the levels of GSH, TAS, and CAT activity. Conclusion: THSN attenuated the KA-induced oxidative stress in the rat hippocampus through its antioxidant effects.

Item Type: Article (Journal)
Uncontrolled Keywords: antioxidant, hippocampus, kainic acid, oxidative stress, protective effect, rats' model, silver nanoparticles, Tualang honey
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Basic Medical
Kulliyyah of Medicine
Depositing User: Mrs Norsyafini Ahmad Marzuki
Date Deposited: 09 Feb 2023 09:20
Last Modified: 09 Feb 2023 09:22
URI: http://irep.iium.edu.my/id/eprint/103597

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