The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection

Che Mohd Nassir, Che Mohd Nasril and Damodaran, Thenmoly and Ismail, Nurul Iman and Hashim, Sabarisah and Jaffer, Usman and Abdul Hamid, Hafizah and Mehat, Muhammad Zulfadli and Norazit, Anwar and Mustapha, Muzaimi (2023) The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection. Life, 13 (1). pp. 1-17. E-ISSN 2075-1729

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Abstract

In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSVD). Although NLRP3 inflammasome-interleukin (IL)-1β has been implicated in the pathophysiology of coronary artery disease, its roles in cerebral arteriothrombotic micro-circulation disease such as CSVD remains unexplored. Here, we elaborate on the current manifestations of CSVD and its’ complex pathogenesis and relate the array of activators and aberrant activation involving NLRP3 inflammasome with this condition. These neuroinflammatory insights would expand on our current understanding of CSVD clinical (and subclinical) heterogenous manifestations whilst highlighting plausible NLRP3-linked therapeutic targets.

Item Type:	Article (Journal)
Uncontrolled Keywords:	cerebral small vessel disease; NLRP3 inflammasome; cerebral ischemia; therapeutics; aging
Subjects:	R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC633 Specialties of Internal Medicines- Diseases of The Blood and Blood-forming Organs. Hematologic Diseases R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Islamic Revealed Knowledge and Human Sciences > Department of Fundamental and Inter-Disciplinary Studies (Effective: 5th Feb 2014) Kulliyyah of Islamic Revealed Knowledge and Human Sciences
Depositing User:	Dr Usman Jaffer
Date Deposited:	13 Jan 2023 16:11
Last Modified:	13 Jan 2023 16:11
URI:	http://irep.iium.edu.my/id/eprint/103207

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