Comparison of various creatinine-based estimates of glomerular filtration rate equations in the Malaysian setting

Mohd Hanafiah, Farah Nadia and Md Ralib, Azrina and Abd Rahim, Mohamad Shahrir (2022) Comparison of various creatinine-based estimates of glomerular filtration rate equations in the Malaysian setting. Medical Journal of Malaysia, 77 (6). pp. 684-688. ISSN 0300-5283

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Abstract

Introduction: Kidney disease is a worldwide health concern with an increasing mortality in the past 10 years. The Kidney Disease Improving Global Outcomes (KDIGO) guideline advocates the use of estimated glomerular filtration rate equation (eGFR) to estimate renal function. Objectives: We evaluated the performance of Cockroft Gault (CG), Modified Diet of Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations to measured GFR 99mTc-DTPA taking into account of body mass index (BMI) and age group. Methods: This is a cross sectional study of patients referred for 99mTc-DTPA scan at the Nuclear Medicine Centre of International Islamic University Malaysia. The record was taken from patients visiting the centre from January 2016 to December 2019. Results: The mean measured GFR by 99mTc-DTPA scan was 42.2 ± 20.38 ml/min, these was lower than that estimated by CG, MDRD and CKD-EPI equations. CKD-EPI had the highest correlation of 0.72, least bias (mean bias of 11.08 ± 23.08) and was more precise (r2 of 0.4) as compared to MDRD and CG. In patients < 65 years old, CKD-EPI had the highest correlation however MDRD had the least bias and highest accuracy. In terms of BMI, CKD-EPI had the least bias and highest accuracy for BMI >30 and with highest correlation for all classes of BMI. Conclusion: CKD-EPI has the best estimation of GFR taking into account the effect of BMI and age. A further study can be done to determine the correlation of estimated GFR equations with different ethnicity in Malaysia.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Chronic kidney disease, Chronic Kidney Disease Epidemiology equation, Modified Diet in Renal Disease equation, Cockroft Gault equation
Subjects:	R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care Kulliyyah of Medicine > Department of Radiology
Depositing User:	Dr Farah Nadia Mohd Hanafiah
Date Deposited:	10 Jan 2023 12:18
Last Modified:	10 Jan 2023 12:19
URI:	http://irep.iium.edu.my/id/eprint/103065

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