Role of catecholamines in young adults with essential hypertension

Abdullah, Aszrin and Mohd Shah, Azarisman Shah and Abdul Razak, Tariq and Mohd Noor, Noriah (2011) Role of catecholamines in young adults with essential hypertension. In: The 8th Annual Scientific Meeting, Malaysian Society of Hypertension, 14-16 January 2011, Kuala Lumpur.

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Abstract

Background: Hypertension is a major cause of cardiovascular morbidity and mortality worldwide, and blood pressure (BP) control is poor. Adrenaline has been suggested to play a role in the pathogenesis of essential hypertension. Objective: The aim of this study is to ascertain the role of adrenaline and noradrenaline (NA) in young pre-hypertensive and mildly hypertensive subjects using standardized and improved methods in patient preparation, blood sample collection and analysis. Methods and Materials: A total of 484 subjects were screened at a primary health care clinic in Kuantan, Malaysia. 91 subjects with systolic and diastolic BP ranges of between 120 - 159 mmHg and 80 - 99 mmHg respectively (pre- and mildly hypertensive groups) and optimally normotensive, age-matched controls between the ages of 20 and 45 were enrolled into a cross-sectional study. Simple demographic data, blood samples for plasma catecholamine and BP were observed. Reversed-phase High Performance Liquid Chromatography with electrochemical detection was used for the determination of plasma catecholamine. Results: The mean age of the subjects were 32.17 ± 6.21 years. In the patient groups, 46.30% had pre-hypertension BP and 53.70% had mild hypertension. Plasma adrenaline, NA and dopamine levels in the patient group (26.58 ± 36.04, 94.43 + 166.54, 52.43 ± 66.62) were significantly greater (p = 0.01, 0.02, 0.02) than age matched-controls with optimally normotensive BP (12.04 ± 9.93, 37.18 + 62.14, 27.06 ± 34.49). Statistically significant differences in plasma adrenaline and dopamine levels were seen between the pre-hypertensive and optimally normotensive BP groups (p=0.002 and p=0.01, respectively). The pre-hypertensive BP group’s plasma adrenaline were also significantly higher than mild hypertension group (p=0.04). Within the patient groups, the mean arterial pressure (MAP) was weakly correlated with plasma adrenaline (r= -0.34, p=0.01), NA (r= -0.28, p=0.04) and dopamine levels (r= -0.29, p=0.04). Conclusion: Our study has shown that there is increased plasma adrenaline in young, pre- and mildly hypertensive subjects. There is also a weak inverse relationship between adrenaline and the MAP. It appears to support adrenaline’s role in the pathogenesis of essential hypertension in very early stages of hypertension development.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	3960/10257
Uncontrolled Keywords:	catecholamines, hypertension, cardiovascular disease
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Prof Noriah Mohd Noor
Date Deposited:	23 Feb 2012 11:15
Last Modified:	23 Feb 2012 11:15
URI:	http://irep.iium.edu.my/id/eprint/10257

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