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The value of c-reactive protein/albumin ratio in the severity and mortality in COVID-19 patients

M, Norsyuhadah and WA, Wan Norlina and MN, Nor Amirah and MJ, Aniza and TI, Tuan Ismail and H, Azian and Y, Najib Majdi and S, Sarina and Kuttulebbai Naina Mohamed Salam, Sirajudeen and CM, Mahaya (2022) The value of c-reactive protein/albumin ratio in the severity and mortality in COVID-19 patients. Malaysian Journal of Public Health Medicine, 22 ((Suppl (2)). p. 106. ISSN 1675-0306 E-ISSN 2590-3829

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The continuing coronavirus disease 2019 (COVID-19) pandemic provides several concerns for physicians. Thus, saving maximum lives as possible and finding people at risk of serious problems is essential. This study aimed to determine the association of CRP/albumin ratio with severity, duration of hospital stay and mortality in COVID-19 patients. The patient aged 18 to 80 with positive COVID-19 at Hospital Raja Perempuan Zainab II (HRPZ II), Kota Bharu, Kelantan, with available CRP/albumin ratio data on admission, were retrospectively evaluated from March 2021 to March 2022. Disease severity was categorized based on Annex 2e guidelines by Malaysia's Ministry of Health, which further classified them into mild to moderate disease (Stage 1-3) and severe to critical illness (Stage 4- 5). The CRP/albumin ratio levels on Day 1 admission were archived from the electronic medical record system and compared between the two groups. The study included 141 COVID-19 patients with a mean age of 51.11(SD± 16.66) for mild to moderate and 58.06 (SD± 13.87) for severe to critical. The severe to critical group had significantly higher values of patients’ age (p=0.015). The frequency of patients according to severity, 36(26%) were mild to moderate, and 105(74%) were severe to critical. CRP/Alb ratio was significantly elevated in the severe to critical illness group (p<0.001). 28 (20%) patients died, 113 (80%) survived, and median CRP/albumin ratio values were higher in non-survivors compared to survivors (p<0.001). High CRP/albumin ratio levels were associated with longer hospital stay (correlation coefficients 0.295, p<0.001). Receiver operator characteristic analysis showed that the area under the curve (AUC) for CRP/albumin ratio was 0.755 (95% CI: 0.670- 0.840). The optimal cut-off point of CRP/albumin ratio was 1.494 (sensitivity 60%, specificity 89%, PPV 0.94, NPV 0.43, LR+ 5.41, LR- 0.45, DOR 12). CRP/Alb ratio on Day 1 admission is associated with COVID-19 severity and mortality.

Item Type: Article (other)
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Date Deposited: 29 Dec 2022 15:43
Last Modified: 29 Dec 2022 15:45
URI: http://irep.iium.edu.my/id/eprint/102376

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