Aging and wound healing of the skin: a review of clinical and pathophysiological hallmarks

Khalid, Kamarul Ariffin and Mohd Nawi, Ahmad Faris and Zulkifli, Nuraqilah and Barkat, Md. Abul and Ab. Hadi, Hazrina (2022) Aging and wound healing of the skin: a review of clinical and pathophysiological hallmarks. Life, 12 (12). pp. 1-12. ISSN 2075-1729

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Abstract

Abstract: Aging is a universal process that can cause diminished function of organs and various diseases. The most striking consequences of aging can be seen visibly on the skin, which acts as a barrier against various external insults. Aging of the skin consists of intrinsic and extrinsic processes that work in concert and influence each other. Intrinsic aging involves biochemical degenerative processes that gradually takes place with age. Extrinsic aging are biochemical processes driven by external influences that lead to aging. There are significant morphological changes at all levels in aged skin that have a profound effect on the characteristics of the skin. Even though skin is subjected to damage by external insults, it is equipped with a healing capability in order to restore its normal structure and function. However, aging has a significant impact on the skin’s healing function by prolonging the inflammatory phase and increasing the production of reactive oxygen species (ROS). This shifts the healing process towards having more protein degradation, which can lead to chronic wound healing with an abundance of complications.

Item Type:	Article (Journal)
Uncontrolled Keywords:	intrinsic aging; extrinsic aging; wound healing; aged skin
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Medicine Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	Dr Hazrina Ab Hadi
Date Deposited:	27 Dec 2022 09:50
Last Modified:	12 Nov 2025 15:32
URI:	http://irep.iium.edu.my/id/eprint/102249

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