IIUM Repository

Antibody response against severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccines in infected individuals: a systematic review

Roslan, Madihah and Mohd Nisfu, Farah Ratulfazira and Arzmi, Mohd Hafiz and Abdul Wahab, Ridhwan and Zainuddin, Norafiza (2023) Antibody response against severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccines in infected individuals: a systematic review. Malaysian Journal of Medical Sciences, 30 (4). pp. 8-24. ISSN 1394-195X E-ISSN 2180-4303

[img] PDF (Article) - Published Version
Restricted to Registered users only

Download (637kB) | Request a copy
PDF (SCOPUS) - Supplemental Material
Download (780kB) | Preview
PDF (WOS) - Supplemental Material
Download (343kB) | Preview


Individuals with a history of coronavirus disease 2019 (COVID-19) exhibit memory immunity acquired during natural infection. However, a decline in immunity after infection renders these individuals vulnerable to re-infection, in addition to a higher risk of infection with new variants. This systematic review examined related studies to elucidate the antibody response in these infected individuals after messenger RNA (mRNA) vaccination. Hence, the focus of this review was to ascertain differences in the concentration of binding and neutralizing antibodies of previously infected individuals in comparison to those of infection-naïve individuals after administration of two doses of mRNA vaccination through available case-control and cohort studies. Positive reverse transcriptase-polymerase chain reaction test or detectable anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at the baseline in included studies showed categorization of infected and uninfected individuals. This review utilized three online databases: PubMed, Scopus, and Cochrane with the following keywords: (COVID-19 OR “Coronavirus Disease 2019” OR SARS-CoV-2) AND Immun* AND (Pfizer OR BioNTech OR BNT162b2 OR Comirnaty OR Moderna OR mRNA-1273) from January 2019 to July 2021. Following Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol guidelines and assessment based on the Crowe Critical Appraisal Tool, we included 13 related qualified papers of observational studies discerning the binding and neutralizing antibody concentrations of infected and uninfected individuals after administration of mRNA vaccines, such as the BNT162b2 and mRNA-1273 vaccine. The mRNA vaccines induced robust binding and neutralizing antibody responses in both groups. However, infected individuals showed induction of higher antibody responses in a shorter time compared to uninfected individuals. Hence, a single dose of mRNA vaccination for infected individuals may be sufficient to reach the same level of antibody concentration as that observed in uninfected individuals after receiving two doses of vaccination.

Item Type: Article (Review)
Additional Information: 7855/102032
Uncontrolled Keywords: COVID-19, SARS-CoV-2, mRNA vaccine, vaccine, antibodies, antibody response
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RA Public aspects of medicine > RA644.C67 Coronavirus infections. COVID-19 (Disease). COVID-19 Pandemic, 2020
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Kulliyyah of Dentistry
Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User: Dr. Norafiza Zainuddin
Date Deposited: 14 Feb 2023 14:34
Last Modified: 21 Jun 2024 10:45
URI: http://irep.iium.edu.my/id/eprint/102032

Actions (login required)

View Item View Item


Downloads per month over past year