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Role of Cystatin C in predicting acute kidney injury after surgery

Mustapha, Muhammad Ikhwan and Othman, Ahmad Faidzal and Mat Nor, Mohd Basri and Md Ralib, Azrina and Ab Rahman, Jamalludin and Elagili, Faisal (2022) Role of Cystatin C in predicting acute kidney injury after surgery. In: 23rd General Scientific Meeting of Singapore Society of Anaesthesiologists, 09-11 December 2022, NTUC Tower, Singapore. (Unpublished)

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Introduction Surgery is a known risk factor for acute kidney injury (AKI) which causes considerable implications on mortality and morbidity. We investigated the incidence of AKI following surgery and determine the diagnostic capability of Cystatin C (CysC) in diagnosing and predicting AKI. Method This is a single centre, prospective study of patients who underwent surgery under general or regional anaesthesia between September 2021 to February 2022. Serum Creatinine and plasma CysC were measured at three intervals (admission, within 24 hours and 72 hours following surgery). Area under receiver operating characteristic curve (AUROC) analysis was used to derive the CysC cut-off value to diagnose and predict AKI. AKI was defined based on creatinine criteria of the Kidney Disease: Improving Global Outcome (KDIGO) criteria. Result A total of 100 patients included with mean age of 58 ± 14 years old and 51% were male. AKI occurred in 20 (20%) patients, mainly stage 1 (55%), followed by stage 2 (30%) and stage 3 (15%). On AUROC analysis, CysC has the highest AUC at 0.93 (Sensitivity 87.7%, Specificity 86.7%) with a cut-off value at 1.67mg/dL for AKI on day three after surgery. Post operative day one CysC predicts day three AKI at a cut-off value of 1.595mg/dL AUC=0.86, (Sensitivity 87.5%, Specificity 79.5%)]. Conclusion Cystatin C is a strong predictor for AKI as early as 1 day following surgery with a cut-off value at 1.595mg/dL. Early recognition of patients at risk to develop AKI may prompt surgeons to be vigilant in managing at-risk patients postoperatively.

Item Type: Conference or Workshop Item (Poster)
Uncontrolled Keywords: Acute Kidney Injury; AKI, Cystatin C; Surgery; Postoperative
Subjects: R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Kulliyyah of Medicine > Department of Community Health & Family Medicine
Kulliyyah of Medicine > Department of Surgery
Depositing User: Asst Prof Faisal Elagili
Date Deposited: 26 Dec 2022 13:22
Last Modified: 26 Dec 2022 13:22
URI: http://irep.iium.edu.my/id/eprint/101941

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