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Prevalence and factors associated with augmented renal clearance after surgery

Mustapha, Muhammad Ikhwan and Othman, Ahmad Faidzal and Mat Nor, Mohd Basri and Md Ralib, Azrina and Ab Rahman, Jamalludin and Elagili, Faisal (2022) Prevalence and factors associated with augmented renal clearance after surgery. In: 23rd General Scientific Meeting of Singapore Society of Anaesthesiologists, 09-11 December 2022, Ntuc Tower, Singapore. (Unpublished)

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Introduction Augmented Renal Clearance (ARC) has been described mainly in critically ill patients which may place patients at risk of therapeutic failure. We investigated the prevalence of ARC following surgery, determine the risk factors and the outcome. Method This is a single centre, prospective study of patients who underwent surgery under general or regional anaesthesia between September 2021 to February 2022. Serum Creatinine, urine Creatinine and 4-hour urine volume were measured within 24 hours following surgery. The significant risk actors for ARC were evaluated by using multiple logistic regression model. ARC was defined as measured Creatinine Clearance >130ml/min/1.73m2. Result A total of 75 patients were included with a mean age of 57 ± 14 years old and 59% were female. ARC occurred in 20 (27%) patients within 24 hours following surgery. The mean age for ARC group was 47.7 ± 13.3 as compared to 60.9 ± 13.6 years old in the No ARC group. On multiple logistic regression analysis, only younger age was found to be an independent predictor for ARC (p< 0.001) (OR 0.9, 95% CI 0.9-1.0). 85% of patients in the ARC cohort were not nursed in the ICU postoperatively (p=0.04). Although patients in the ARC cohort required longer hospital stay (24.7 ± 36.5 vs. 12.7 ± 14.4 days), the figure was not statistically significant (p=0.197). Conclusion Significant proportion of ARC were identified among patients underwent surgery whom did not require ICU admission postoperatively. This represents an important finding as ARC is a key predictor for subtherapeutic drug concentrations

Item Type: Conference or Workshop Item (Slide Presentation)
Uncontrolled Keywords: Augmented Renal Clearance; ARC; Surgery; Postoperative
Subjects: R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Kulliyyah of Medicine > Department of Community Health & Family Medicine
Kulliyyah of Medicine > Department of Surgery
Depositing User: Asst Prof Faisal Elagili
Date Deposited: 26 Dec 2022 13:15
Last Modified: 26 Dec 2022 13:15
URI: http://irep.iium.edu.my/id/eprint/101938

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