Differentiation of osteoblasts: the links between essential transcription factors

Khotib, Junaidi and Marhaeny, Honey Dzikry and Miatmoko, Andang and Budiatin, Aniek Setiya and Chrismawan, Ardianto and Rahmadi, Mahardian and Pratama, Yusuf Alif and Bakhtiar, M. Taher (2022) Differentiation of osteoblasts: the links between essential transcription factors. Journal of Biomolecular Structure and Dynamics. ISSN 0739-1102 E-ISSN 1538-0254 (In Press)

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Abstract

Osteoblasts, cells derived from mesenchymal stem cells (MSCs) in the bone marrow, are cells responsible for bone formation and remodeling. The differentiation of osteoblasts from MSCs is triggered by the expression of specific genes, which are subsequently controlled by pro-osteogenic pathways. Mature osteoblasts then differentiate into osteocytes and are embedded in the bone matrix. Dysregulation of osteoblast function can cause inadequate bone formation, which leads to the development of bone disease. Various key molecules are involved in the regulation of osteoblastogenesis, which are transcription factors. Previous studies have heavily examined the role of factors that control gene expression during osteoblastogenesis, both in vitro and in vivo. However, the systematic relationship of these transcription factors remains unknown. The involvement of ncRNAs in this mechanism, particularly miRNAs, lncRNAs, and circRNAs, has been shown to influence transcriptional factor activity in the regulation of osteoblast differentiation. Here, we discuss nine essential transcription factors involved in osteoblast differentiation, including Runx2, Osx, Dlx5, b-catenin, ATF4, Ihh, Satb2, and Shn3. In addition, we summarize the role of ncRNAs and their relationship to these essential transcription factors in order to improve our understanding of the transcriptional regulation of osteoblast differentiation. Adequate exploration and understanding of the molecular mechanisms of osteoblastogenesis can be a critical strategy in the development of therapies for bone-related diseases.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Bone development, bone remodeling, osteoblast differentiation, essential transcription factors, molecular mechanisms, transcriptional regulation, bone disorders, ncRNAs
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Pharmacy
Depositing User:	Dr Muhammad Taher
Date Deposited:	29 Nov 2022 09:12
Last Modified:	29 Nov 2022 09:12
URI:	http://irep.iium.edu.my/id/eprint/101462

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