Enrichment of antibacterial compound from the stem bark of Stereospermum fimbriatum using supercritical carbon dioxide extraction

Awang, Anis Fadhlina Izyani and Sarker, Md Zaidul Islam and Ahmed, Qamar Uddin and Md. Jaffri, Juliana and Sheikh Mohamed, Hassan Ibrahim and Ferdosh, Sahena (2019) Enrichment of antibacterial compound from the stem bark of Stereospermum fimbriatum using supercritical carbon dioxide extraction. Separation Science and Technology, 55 (9). pp. 1656-1666. ISSN 0149-6395 E-ISSN 1520-5754

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Abstract

Supercritical carbon dioxide (sc-CO2) extraction was carried out on Stereospermum fimbriatum’s stem bark in order to obtain an enriched extract containing the targeted active compound. The recovery of its active compound, C1, was compared with the most active Soxhlet’s extract of dichloromethane. A minimum inhibitory concentration (MIC) assay was done to examine the antibacterial activity of extracts against methicillin-resistant Staphylococcus aureus. The optimum condition for an enriched extract of sc-CO2 to have a maximum recovery of C1 at MIC value of 400 µg/mL was suggested to be operated at 40°C and pressure at 30 MPa, with addition of 6% co-solvent.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Supercritical carbon dioxide extraction, stereospermum fimbriatum, antibacterial activity, full factorial design
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Dr. Anis Fadhlina
Date Deposited:	21 Nov 2022 13:16
Last Modified:	05 Dec 2022 17:39
URI:	http://irep.iium.edu.my/id/eprint/101142

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