Recent development on the synthesis of thiourea derivatives and effect of substituents on the anticancer activity: a short review

Roslan, Norashikin and Muhamad Bunnori, Noraslinda and Abdul Halim, Khairul Bariyyah and Kassim, Karimah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Ngah, Nurziana (2022) Recent development on the synthesis of thiourea derivatives and effect of substituents on the anticancer activity: a short review. Malaysian Journal of Analytical Sciences, 26 (5). pp. 1047-1069. ISSN 1394-2506

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Abstract

Thiourea is a carbon, hydrogen, sulphur, and nitrogen-based organic molecule. The thiourea group has been improved by replacing various substituents for its hydrogen atoms at the nitrogen terminal, resulting in a wide range of biological activities, especially on anticancer properties. Despite the fact that thiourea derivatives have remarkable anticancer potential, finding a novel anticancer agent that is both safe and selective remains a challenge. This paper summarizes recent research on thiourea compounds that can be used to treat malignant cell lines. Several synthesis methods and the effects of substituents as well as their anticancer therapeutic potential in a variety of healthy and malignant cell lines are discussed. As a result, it is envisaged that this review will guide the design and synthesis of new thiourea derivatives in the future for the development of highly effective and selective anticancer drug

Item Type:	Article (Journal)
Uncontrolled Keywords:	thiourea derivatives, synthesis method, anticancer activity, substituents
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry Kulliyyah of Science
Depositing User:	Dr Nurziana Ngah
Date Deposited:	31 Oct 2022 15:56
Last Modified:	31 Oct 2022 15:58
URI:	http://irep.iium.edu.my/id/eprint/100898

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