Razali, Khairiah and Algantri, Khaled and Su, Peng Loh and Shi-, Hui Cheng and Mohamed, Wael Mohamed Yousef
(2022)
Integrating nutriepigenomics in Parkinson’s disease management: new promising
strategy in the Omics era.
IBRO Neuroscience Reports.
ISSN 2667-2421
(In Press)
Abstract
Parkinson’s disease (PD) is the most prevalent brain motor disorder and is frequently
regarded as an idiopathic and sporadic disease due to its unclear etiology. Although the
pathological mechanisms of PD have already been investigated at various omics levels, no
disease-modifying drugs are currently available. At the moment, treatments can only provide
symptomatic relief to control or improve motor symptoms. Parkinson’s disease is a
multifactorial disease, the development and progression of which are influenced by multiple
factors, including the genetic markups and the environment. As an indispensable component
of our daily life, nutrition is considered one of the most robust environmental factors
affecting our health. Consequently, depending on our dietary habits, nutrition can either
induce or reduce our susceptibility to PD. Epigenetic mechanisms regulate gene expression
through DNA methylation, histone modifications, and non-coding RNAs (ncRNAs) activity.
Accumulating evidence from nutriepigenomics studies has reported altered epigenetic
mechanisms in clinical and pre-clinical PD models, and the potential role of nutrition in
modifying the changes. In addition, through nutrigenetics and nutrigenomics studies, the diet-
gene, and gene-diet interactions concerning PD development and progression have been
investigated. Herein, current findings on the roles of nutrition in epigenetic mechanisms
underpinning PD development and progression are discussed. Recent advancements in the
multi-omics approach in PD nutrition research are also underlined. The ability of nutrients to
influence epigenetic mechanisms and the availability of multi-omics applications compel the
immediate use of personalized nutrition as adjuvant therapy for PD
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