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Streptococcus gallolyticus infection: a neglected marker for colorectal cancer?

Ismail, Che Muhammad Khairul Hisyam and Aidid, Edre Mohammad and Hamzah, Hairul Aini and Shalihin, Shaiful Ehsan and Md Nor, Azmi (2022) Streptococcus gallolyticus infection: a neglected marker for colorectal cancer? In: Malaysian Society for Microbiology Postgraduate Symposium (MSMPS2022), 10-11 August 2022, Online. (Unpublished)

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Colorectal cancer (CRC) is the second leading cancer in Malaysia with mostly detected at later stage, III and IV due to lack of awareness of CRC symptoms and signs. CRC is a multifactorial, however the clinical association of Streptococcus gallolyticus (S. gallolyticus) infection with the development of colorectal cancer were reported. Thus, a case-control study was conducted to identify the correlation and predictors of S. gallolyticus infection towards CRC among patients attending Sultan Ahmad Shah Medical Centre@IIUM. A total of 33 stool sample from patient diagnosed with CRC and 80 stool sample from patient without CRC attending Sultan Ahmad Shah Medical Centre@IIUM were collected and proceeded with iFOBT test and PCR assay for detection of S. gallolyticus.. In this study, the proportion of S. gallolyticus infection was higher among CRC patients (48.5%) as compared to the control group (20%). The Pearson’s, χ2 or Fisher’s exact analysis shows that the presence of occult blood in stool, S. gallolyticus infection, and family history were significantly associated with the development of CRC (p-value < 0.05). The best multivariate logistic regression model showed that positive stool PCR for S. gallolyticus had the lowest relative standard error (RSE) and almost 5 times the odds to develop CRC after controlling other factors (adjusted odds ratio= 4.7, 95% confidence interval= 1.7 – 12.6, RSE = 59.6%). This finding suggested that the S. gallolyticus infection was the strongest predictor towards development of CRC and potentially be used as a predictive marker for early detection of disease progression.

Item Type: Conference or Workshop Item (Other)
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC270 Neoplasms. Tumors. Oncology-Cancer and Other Malignant Neoplasms-Therapeutics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Depositing User: Dr Hairul Aini Hamzah
Date Deposited: 20 Sep 2022 14:45
Last Modified: 20 Sep 2022 14:45
URI: http://irep.iium.edu.my/id/eprint/100025

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