IIUM Repository

The relationship between retinal nerve fibre layer thickness and total retinal blood flow in primary open angle claucoma

Flanagan, John G and Yusof @ Alias, Firdaus and Cheng, Richard and Tayyari, Faryan and Espahbodi, Nadia and Khuu, Lee-Anne and M Buys, Yvonne and Trope, Graham and Hudson, Christopher (2014) The relationship between retinal nerve fibre layer thickness and total retinal blood flow in primary open angle claucoma. Investigative Ophthalmology & Visual Science, 55 (13). p. 953. ISSN 0146-0404 E-ISSN 1552-5783

[img] PDF (Abstract) - Published Version
Restricted to Registered users only

Download (173kB) | Request a copy


Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls. Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Field Analyzer, HFA, mean deviation, MD, -2.28±3.85) and 33 healthy controls (age, 63±5 years; HFA MD -0.48±1.56) were recruited. The Doppler SD-OCT retinal blood flow measurement was taken using the circum-papillary double circular scan protocol in the RTVue system (Optovue Inc., Freemont, CA, USA). A minimum of six RBF scans were acquired. Flow parameters were calculated only from the valid scans. Peri-papillary RNFL thickness was measured using RTVue’s RNFL scan protocol. Results: The total RBF in the POAG group was significantly lower than in the control group (group mean POAG RBF = 30.61±9.29µL/min; group mean control RBF = 40.68±11.32µL/min; p=<0.01). Superior and inferior RBF were also significantly lower in the POAG group (p=<0.01 for both superior & inferior RBF). The average RNFL thickness, superior and inferior RNFL thickness were significantly lower in the POAG group (p=<0.01). Linear regression analysis showed a significant positive correlation between the total RBF and average RNFL thickness (r=0.38, p=0.03), and the superior RBF and superior RNFL thickness (r=0.37, p=0.01). There was no correlation between the inferior RBF and RNFL thickness (r=0.30, p=0.09). Conclusions: There was an association between thinning of the RNFL and reduced inner retinal perfusion in the eyes of patients with POAG.

Item Type: Article (other)
Uncontrolled Keywords: nerve fiber layer, blood supply, imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)
Subjects: R Medicine > RE Ophthalmology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Basic Health Sciences (Until June 2011)
Depositing User: Dr Firdaus Yusof
Date Deposited: 15 Sep 2022 11:42
Last Modified: 15 Sep 2022 12:16
URI: http://irep.iium.edu.my/id/eprint/100001

Actions (login required)

View Item View Item


Downloads per month over past year