IIUM Repository

Enrichment of antibacterial compound from the stem bark of Stereospermum fimbriatum using supercritical carbon dioxide extraction

Awang, Anis Fadhlina Izyani and Sarker, Md. Zaidul Islam and Ahmed, Qamar Uddin and Md Jaffri, Juliana and Sheikh, Hassan I. and Ferdosh, Sahena (2020) Enrichment of antibacterial compound from the stem bark of Stereospermum fimbriatum using supercritical carbon dioxide extraction. Separation Science and Technology (Philadelphia), 55 (9). pp. 1656-1666. ISSN 0149-6395 E-ISSN 1520-5754

[img]
Preview
PDF (scopus) - Supplemental Material
Download (431kB) | Preview

Abstract

Supercritical carbon dioxide (sc-CO2) extraction was carried out on Stereospermum fimbriatum’s stem bark in order to obtain an enriched extract containing the targeted active compound. The recovery of its active compound, C1, was compared with the most active Soxhlet’s extract of dichloromethane. A minimum inhibitory concentration (MIC) assay was done to examine the antibacterial activity of extracts against methicillin-resistant Staphylococcus aureus. The optimum condition for an enriched extract of sc-CO2 to have a maximum recovery of C1 at MIC value of 400 µg/mL was suggested to be operated at 40°C and pressure at 30 MPa, with addition of 6% co-solvent.

Item Type: Article (Journal)
Additional Information: 6605/82296
Uncontrolled Keywords: antibacterial activity, full factorial design, stereospermum fimbriatum, Supercritical carbon dioxide extraction
Subjects: S Agriculture > S Agriculture (General)
S Agriculture > SB Plant culture
T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science
Depositing User: Professor Md. Zaidul Islam Sarker
Date Deposited: 26 Aug 2020 14:40
Last Modified: 26 Aug 2020 14:40
URI: http://irep.iium.edu.my/id/eprint/82296

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year