TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia

Zainuddin, Norafiza and Murray, Fiona and Kanduri, Meena and Gunnarsson, Rebeqa and E. Smedby, Karin and Enblad, Gunilla and Jurlander, Jesper and Juliusson, Gunnar and Rosenquist, Richard (2011) TP53 mutations are infrequent in newly diagnosed chronic lymphocytic leukimia. Leukemia Research, 35 (2). pp. 272-274. ISSN 0145-2126

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Abstract

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3–6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression.

Item Type:	Article (Journal)
Additional Information:	4623/4434
Uncontrolled Keywords:	TP53 mutation, 17p-deletion, Prognosis, Chronic lymphocytic leukemia
Subjects:	R Medicine > RC Internal medicine > RC254 Neoplasms. Tumors. Oncology (including Cancer)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Dr. Norafiza Zainuddin
Date Deposited:	25 Nov 2016 15:23
Last Modified:	25 Nov 2016 15:23
URI:	http://irep.iium.edu.my/id/eprint/52865

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